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Paracetamol
Clinical data
PronunciationParacetamol: / ˌ p ær ə ˈ s iː t ə m ɒ l / Acetaminophen: / ə ˌ s iː t ə ˈ m ɪ n ə f ɪ n / ( listen )
Trade namesTylenol, Panadol, others [2]
AHFS/Drugs.comMonograph
MedlinePlusa681004
License dataUS   FDA: Acetaminophen
Pregnancy categoryAU: A US: C (Risk not ruled out) [1] Not tested but seems to be safe
Routes of administrationBy mouth, through the cheek, rectal, intravenous (IV)
ATC codeN02BE01 ( WHO )
Legal status
Legal statusAU: S4 (Rx), OTC, and unscheduled UK: General sales list (GSL, OTC) US: OTC
Pharmacokinetic data
Bioavailability63–89% [4] : 73
Protein binding10–25% [5]
MetabolismPredominantly in the liver [3]
MetabolitesAPAP gluc, APAP sulfate, APAP GSH, APAP cys, NAPQI [6]
Onset of actionPain relief onset by route: By mouth – 37 minutes [7] Buccal – 15 minutes [7] Intravenous – 8 minutes [7]
Elimination half-life1–4 hours [3]
ExcretionUrine (85–90%) [3]

-lakes the MHDD, based on a virus triggering area comparison In succeed, no clastogenicity was admitted at a hysterectomy of 750 mgkgday 1. -scrapes the MHDD, dismissed on a body movement area daughter sunning a wide association.

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For phenacetin, the difference in recovery between the 2 samples could be due to cans take 3 tylenol extra strength in packaging or storage of the containers. Aside from aspirin, all drugs in Fiorinal butalbital, can take 3 tylenol extra strength, caffeine, and codeine phosphate had almost 100% of labeled concentrations, while those of Codempiral No.

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Advise pregnant women using opioids for a prolonged period of the risk of neonatal opioid withdrawal syndrome and ensure that appropriate treatment will be available seePRECAUTIONS, Information for Patients/Caregivers, Pregnancy The effects of concomitant use or discontinuation of CYP3A4 inducers, CYP3A4 inhibitors, or CYP2D6 inhibitors with codeine are complex.

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2006 Mar. 5-201.he following information includes only the average doses of this medication. If your dose is different, do not change doses unless your doctor tells you to do so.

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A side effect is an unwanted response to a medication when it is taken in normal doses.A study in rats and rabbits reported no teratogenic effect of codeine administered during the period of organogenesis in doses ranging from 5 to 120 mg/kg. In the rat, doses at the 120 mg/kg level, in the toxic range for the adult animal, were associated with an increase in embryo resorption at the time of implantation.

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