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Amlodipine
Clinical data
Pronunciation/ æ m ˈ l oʊ d ɪ ˌ p iː n / [1]
Trade namesNorvasc, others
AHFS/Drugs.comMonograph
MedlinePlusa692044
License dataEU  EMA:  by INN, US  DailyMed:  Amlodipine, US   FDA: Amlodipine
Pregnancy categoryAU: C US: C (Risk not ruled out)
Routes of administrationBy mouth
Drug classCalcium channel blocker
ATC codeC08CA01 ( WHO )
Legal status
Legal statusIn general: ℞ (Prescription only)
Pharmacokinetic data
Bioavailability64–90%
Protein binding93% [2]
MetabolismLiver
MetabolitesVarious inactive pyrimidine metabolites
Onset of actionHighest availability 6–12 hours after oral dose
Elimination half-life30–50 hours
Duration of actionAt least 24 hours
ExcretionUrine

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