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The use of ezetimibe alone is associated with muscle related events, including rhabdomyolysis.However, consistent with the overall population, the intensive regimen did not reduce overall mortality compared with the moderate regimen.

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In a randomized, double-blind, active-control study Reversal of Atherosclerosis with Aggressive Lipid LoweringREVERSAL in 654 patients with CHD, treatment with intensive antilipemic therapy atorvastatin 80 mg daily or moderate antilipemic therapy pravastatin 40 mg daily for 18 months reduced LDL-cholesterol concentrations to a mean of 79 or 110 mg/dL, respectively; concentrations of C-reactive protein were reduced by 36.

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