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Diphenhydramine
Clinical data
Pronunciation/ ˌ d aɪ f ɛ n ˈ h aɪ d r ə m iː n /
Trade namesBenadryl, Unisom, Sominex, others
AHFS/Drugs.comMonograph
MedlinePlusa682539
Pregnancy categoryAU: A US: B (No risk in non-human studies)
Dependence liabilityVery low
Routes of administrationBy mouth, intramuscular injection, intravenous, topical, rectal
ATC codeD04AA32 ( WHO ) D04AA33 ( WHO ), R06AA02 ( WHO )
Legal status
Legal statusAU: S2 (Pharmacy only) US: OTC
Pharmacokinetic data
Bioavailability40–60% [2]
Protein binding98–99%
MetabolismLiver (CYP2D6 (80%), CYP3A4 (10%)) [1]
Elimination half-lifeRange: 2.4–13.5 hrs [3] [2] [4]
ExcretionUrine: 94% [5] Feces: 6% [5]

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Sip throughout the day.Do not give other cough-and-cold medication that might contain the can i take benadryl with advil or similar ingredients see also Drug Interactions section Ask the doctor or pharmacist about other ways to relieve cough and cold symptoms such as drinking enough fluids, using a humidifier or saline nose drops/spray Take this medication by mouth as directed by your doctor.

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Moral of the story: If you want more of a medication, don't fake a reaction to it. On two separate occasions, I have given IV Benadryl to middle-aged African American women and they had both had this coughing fit and advil benadryl confusion, then became obtunded for a minute or two.All rights reserved.

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Your doctor may also recommend blood or skin tests to see if any underlying causes may contribute to hives. Chronic hives are usually not associated with any serious allergic reactions.Some medicines can cause unwanted or dangerous effects when used together. Not all possible interactions are listed in this medication guide.

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