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Diphenhydramine
Clinical data
Pronunciation/ ˌ d aɪ f ɛ n ˈ h aɪ d r ə m iː n /
Trade namesBenadryl, Unisom, Sominex, others
AHFS/Drugs.comMonograph
MedlinePlusa682539
Pregnancy categoryAU: A US: B (No risk in non-human studies)
Dependence liabilityVery low
Routes of administrationBy mouth, intramuscular injection, intravenous, topical, rectal
ATC codeD04AA32 ( WHO ) D04AA33 ( WHO ), R06AA02 ( WHO )
Legal status
Legal statusAU: S2 (Pharmacy only) US: OTC
Pharmacokinetic data
Bioavailability40–60% [2]
Protein binding98–99%
MetabolismLiver (CYP2D6 (80%), CYP3A4 (10%)) [1]
Elimination half-lifeRange: 2.4–13.5 hrs [3] [2] [4]
ExcretionUrine: 94% [5] Feces: 6% [5]

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Consult your doctor before breast-feeding.Make certain your health care professional knows if you are on a low-sodium, low-sugar, or any other special diet. Most medicines contain more than their active ingredient, and many liquid medicines contain alcohol.

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Consult your doctor before breast-feeding. Drug interactions may change how your medications work or increase your risk for serious side effects.Playing in the grass can cause hives on exposed skin.

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Even fast acting formulas that you place under your tongue may take a good hour or more to work. For those who use melatonin, it s helpful to know that this benadryl syrup dosage for adults works differently than, for example, an antihistamine.Extensive diagnostic workup including basic laboratory testing, brain MRI, CSF analysis, and urine toxicology screen were unremarkable.

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