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Back to top The alternatives to Benadryl vary depending on why you are using the medicine. The following are some of the baby-safe substitutes for Benadryl: Loratadine-based medicine: Loratadine is a drug that can help provide relief from allergy symptoms.Both allergies and infections cause pinkeye, or conjunctivitis. Eye discharge associated with infections is usually accompanied by other symptoms including: Photophobia sensitivity to light can be associated with eye infections.

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