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Clinical data
Pronunciation/ ˌ d aɪ f ɛ n ˈ h aɪ d r ə m iː n /
Trade namesBenadryl, Unisom, Sominex, others
Pregnancy categoryAU: A US: B (No risk in non-human studies)
Dependence liabilityVery low
Routes of administrationBy mouth, intramuscular injection, intravenous, topical, rectal
ATC codeD04AA32 ( WHO ) D04AA33 ( WHO ), R06AA02 ( WHO )
Legal status
Legal statusAU: S2 (Pharmacy only) US: OTC
Pharmacokinetic data
Bioavailability40–60% [2]
Protein binding98–99%
MetabolismLiver (CYP2D6 (80%), CYP3A4 (10%)) [1]
Elimination half-lifeRange: 2.4–13.5 hrs [3] [2] [4]
ExcretionUrine: 94% [5] Feces: 6% [5]

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Even so, some of the older antihistamines, liquid benadryl for toddler as brompheniramine and chlorpheniramine, can bring relief. Newer antihistamines like fexofenadine Allegra and loratidine Claritin have not been shown to work for cold symptoms.This might tempt a person to misuse alcohol and Benadryl as a sleep aid.

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Do not use this benadryl dosage chart for infant without a doctor's advice if you are breast-feeding a baby. Use exactly as directed on the label, or as prescribed by your doctor.isclaimer: Most OTC drugs are not reviewed and approved by FDA, however they may be marketed if they comply with applicable regulations and policies.

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