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To ensure overnight blood pressure control with oral administration, the last dose of the day should be administered immediately before retiring.SedatingDrugs: Clonidine may potentiate the CNS-depressive effects of alcohol, arbiturates or other sedating drugs. 7 Drugs Knownto Affect Sinus Node Function or AV Nodal Conduction: Caution is warrantedin patients receiving clonidine concomitantly with agents known to affectsinus node function or AV nodal conduction e.

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