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Clinical data
Trade namesConvulex, Depakote, Epilim, Stavzor, and others
Pregnancy categoryAU: D US: X (Contraindicated) - only for epilepsy or bipolar if other options are not possible [1]
Routes of administrationBy mouth, intravenous
ATC codeN03AG01 ( WHO )
Legal status
Legal statusAU: S4 (Prescription only) CA : ℞-only UK: POM (Prescription only) US: ℞-only
Pharmacokinetic data
BioavailabilityRapid absorption
Protein binding80–90% [2]
MetabolismHepatic—glucuronide conjugation 30–50%, mitochondrial β-oxidation over 40%
Elimination half-life9–16 hours [2]
ExcretionUrine (30-50%) [2]
Sodium valproate

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This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Data sources include IBM Watson Micromedex updated 10 Aug 2020 Cerner Multum updated 3 Aug 2020 Wolters Kluwer updated 10 Aug 2020 andothers.10: CD003945. doi.

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