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|Trade names||Cataflam, Voltaren, others |
|Pregnancy category||AU: C US: C (Risk not ruled out) in 1st and 2nd trimester, D in 3rd trimester|
|Routes of administration||By mouth, rectal, intramuscular, intravenous (renal- and gallstones), topical|
|ATC code||D11AX18 ( WHO ) M01AB05 ( WHO ), M02AA15 ( WHO ), S01BC03 ( WHO )|
|Legal status||AU: S2 (Pharmacy only) – S4, UK: POM (Prescription only) (P for topical formulation), ℞-only in most preparations/countries, limited OTC in some countries, manufacture and veterinary use is banned in India, Nepal, and Pakistan due to imminent extinction of local vultures|
|Protein binding||More than 99%|
|Metabolism||Liver, oxidative, primarily by CYP2C9, also by CYP2C8, CYP3A4, as well as conjugative by glucuronidation (UGT2B7) and sulfation;  no active metabolites exist|
|Elimination half-life||1.2–2 hr (35% of the drug enters enterohepatic recirculation)|
|Excretion||40% biliary 60% urine|
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Results from clinical studies indicate that diclofenac diclofenac sodium gel buy online ophthalmic solution has no significant effect upon ocular pressure. However, elevations in intraocular pressure may occur following cataract surgery.If you wait until the pain has worsened, the medication may not work as well and cityofneedles.com.
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These food-induced alterations in GI absorption of the drug result from delayed transit of the delayed-release enteric-coated tablets to the small intestine, the site of dissolution.Throw away any unused medicine after the expiration date.
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Diclofenac sodium topical gel was administered at a dose of 4 g, 4 times daily, on 1 diclofenac gel buy online 16 g per day Pain as assessed by the patients at Week 12 using the WOMAC Western Ontario and McMaster Universities Osteoarthritis Index Pain Subindex was lower in the diclofenac sodium topical gel group than the placebo group. Study 2 evaluated the efficacy of diclofenac sodium topical gel for the treatment of osteoarthritis in subjects with osteoarthritis of the hand in an 8-week, randomized, double-blind, multicenter, placebo-controlled, parallel-group study.om/viewarticle/781629.
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