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If signs and symptoms of tardive dyskinesia appear in a patient receiving olanzapine, drug discontinuance or a reduction in dosage should be considered.During antipsychotic treatment, improvement in the patient's clinical condition may take several days to some weeks.

Patients should be closely monitored during this period.

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Olanzapine vs zyprexa FP, Nelson DL, DeLapp NW, olanzapine vs zyprexa al. Antagonism by olanzapine of dopamine D1, serotonin 2, muscarinic, histamine H1, and alpha 1-adrenergic receptors in vitro.A possible limitation of this study is the lack of an active comparator, which has been advocated as a tool in aiding the validity of placebo-controlled studies.

Further comparator studies need to be completed.

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