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Donepezil
Clinical data
Trade namesAricept, others
AHFS/Drugs.comMonograph
MedlinePlusa697032
Pregnancy categoryAU: B3 US: C (Risk not ruled out)
Routes of administrationBy mouth (tablets)
ATC codeN06DA02 ( WHO )
Legal status
Legal statusAU: S4 (Prescription only) US: ℞-only In general: ℞ (Prescription only)
Pharmacokinetic data
Bioavailability100%
Protein binding96%
Elimination half-life70 hours
Excretion0.11-0.13 (L/h/kg)

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New Gloucestershire: Columbia Asking Press; 2003. Braak H, Braak E. Unfair stageing of Alzheimer-related aricept tablets. Mares Neuropathol. aricept tablet 239-59. Medline.

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The metabolism of donepezil hydrochloride is not affected by concurrent administration of donepezil copd or cimetidine.Clearance of donepezil in a limited number of patients with stable alcoholic cirrhosis was reduced by 20% compared with that in healthy age- and gender-matched donepezil copd however, the manufacturer makes no specific recommendation for dosage adjustment in patients with hepatic disease.

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The dose of this medicine will be different for different patients.While the treatment effect size may appear to be slightly greater for the 10 mg/day treatment, there was no statistically significant difference between the two active treatments.

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The treating physician should routinely evaluate the ability of patients on donepezil to continue driving or operating complex machines.as assessed by results of neuropsychological tests and clinicians' impression of change, respectively Age, race, or gender did not predict response to donepezil therapy in these studies. Cognitive function was evaluated with the cognitive subscale of the Alzheimer's Disease Aricept donepezil hcl 5 mg Scale ADAS cog a multiple-item instrument that has been extensively validated in longitudinal cohorts of patients with Alzheimer's disease.

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Figure 13 is a histogram of the frequency distribution of CIBIC-plus scores attained by tabs aricept at the end of 24 weeks of tab aricept. The mean difference between the 23 mg/day and 10 mg/day treatment groups was 0.DSM IV, ICD 10 Therapy with donepezil should only be started if a caregiver is available who will regularly monitor drug intake for the patient.

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