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Famciclovir is rapidly converted in vivo into penciclovir, which has in vitro activity against herpes simplex viruses HSV types 1 and 2 varicella zoster virus VZV Epstein-Barr virus and cytomegalovirus.No clinically significant alterations in penciclovir pharmacokinetics were observed following single-dose administration of 500 mg famciclovir after pretreatment with multiple doses of allopurinol, cimetidine, theophylline, zidovudine, promethazine, when given shortly after an antacid magnesium and aluminum hydroxide or concomitantly with emtricitabine.
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Little or no prodrug is present in plasma or urine.It is not known if Famciclovir tablets can stop the spread of herpes to others.
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