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Ketoconazole
(2 R,4 S )-(+)-ketoconazole (top) (2 S,4 R )-(−)-ketoconazole (bottom)
Clinical data
Pronunciation/ ˌ k iː t oʊ ˈ k oʊ n ə ˌ z oʊ l, - z ɒ l / [1] [2]
Trade namesNizoral, others
AHFS/Drugs.comMonograph
MedlinePlusa682816
License dataEU  EMA:  by INN, US   FDA: Ketoconazole
Pregnancy categoryAU: B3 US: C (Risk not ruled out)
Routes of administrationOral (tablets), topical (cream, shampoo, solution)
ATC codeJ02AB02 ( WHO ) D01AC08 ( WHO ) G01AF11 ( WHO )
Legal status
Legal statusUK: OTC US: OTC
Pharmacokinetic data
BioavailabilityOral: 37–97% [3]
Protein binding84 to 99%
MetabolismExtensive liver (predominantly oxidation, O -dealkylation)
MetabolitesN -deacetyl ketoconazole
Elimination half-lifeBiphasic
ExcretionBiliary (major) and kidney [4]

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