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Reaction with sodium borohydride in the presence of aluminum chloride selectively reduces the double bond to yield the diuretic agent metolazone 5 Metolazone is a quinazoline, a derivative of the similar diuretic quinethazone, as well as a sulfonamide. It is related to analogs of 1, -benzothiadizine-1, -dioxide benzothiadiazine These drugs are called benzothiadiazides, or thiazides for short.Medline.

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Natriuresis is lower even when ECF volume becomes expanded. The reason for these maladaptive changes is remodeling in the distal nephron.Potassium is an essential mineral that is important for the proper function of muscle cells and nerves of the heart and other parts of the body.

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This causes more sodium and water to pass into the collecting duct and be excreted in the urine. They are called Ksparing diuretics because they do not produce hypokalemia like the loop and thiazide diuretics.Probenecid: Pre-treatment ibuprofen 200 mg 60 tabletek cena probenecid reduces both the natriuresis and hyperreninemia produced by bumetanide.

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