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001 histological death hazard ratioHR, 0. 2; P. n atorvastatin 10 mg and HR, 0. 7; P. n atorvastatin 80 mg and all-cause delaying HR, 0.
|Pronunciation||/ ə ˌ t ɔːr v ə ˈ s t æ t ən /|
|Trade names||Lipitor, Atorva, others|
|License data||US DailyMed: 42465, US FDA: Atorvastatin|
|Pregnancy category||AU: D US: X (Contraindicated)|
|Routes of administration||By mouth|
|ATC code||C10AA05 ( WHO )|
|Legal status||AU: S4 (Prescription only) UK: POM (Prescription only) US: ℞-only|
|Elimination half-life||14 hours|
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2 It is possible that the net risk of stroke is increased in patients with prior lacunar infarct who receive atorvastatin 80 mg/day. All cause mortality was.perindopril, lisinopril may also occasionally lead to hair loss in some patients.
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1000 mg/kg/day In rats, increased incidences of common fetal skeletal findings extra pair of thoracic ribs, unossified cervical vertebral centra, shortened ribs were observed at 1000 mg/kg/day ~10 times the human exposure at 10 mg daily based on AUC0-24hr for total ezetimibe In rabbits treated with ezetimibe, an increased incidence of extra thoracic ribs was observed at 1000 mg/kg/day 150 times the human exposure at 10 mg daily based on AUC0-24hr for is atorvastatin 40 mg a high dose ezetimibe Ezetimibe crossed the placenta is atorvastatin 40 mg a high dose pregnant rats and rabbits were given multiple oral doses.We anticipate reposting the images once we are able identify and filter out images that do not match the information provided in the drug labels.
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However, atorvastatin therapy did not reduce is 10 mg atorvastatin enough mortality.This fact should be taken into account if similar studies are designed in future. This study was supported by the research project J.
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Tatins have been associated with increases in HbA1c and fasting serum glucose levels as seen in diabetes.nnual liver function and lipid tests are required by the physician.
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These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.During such concomitant therapy, the lowest necessary dosage of atorvastatin should be employed, and dosage of atorvastatin should not exceed 40 mg daily.
Concomitant use of atorvastatin and ritonavir-boosted saquinavir increases the risk of myopathy or rhabdomyolysis.
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Consider therapy modification CYP3A4 Inhibitors Moderate May decrease the metabolism of CYP3A4 Substrates High risk with Inhibitors Monitor therapy CYP3A4 Inhibitors Strong May decrease the metabolism of CYP3A4 Substrates High risk with Inhibitors Management: Consider avoiding this combination.
Some combinations are specifically contraindicated by manufacturers; others may have recommended dose adjustments.Error bars represent standard deviation.
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Children age 10 and above were initiated at 10 mg atorvastatin once daily All children could titrate to higher doses to achieve a target of 3.The proportions of subjects who experienced non-cardiovascular death were numerically larger in the atorvastatin calcium tablets 80 mg group 5.
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Paediatric use should only be carried out by physicians experienced in the treatment of what is considered a high dose of atorvastatin hyperlipidaemia and patients should be re-evaluated on a regular basis to assess progress.
For patients with Heterozygous Familial Hypercholesterolemia aged 10 years and above, the recommended starting dose of atorvastatin is 10 mg per day see section 5.Statins are highly effective and relatively safe drugs, and are the medication of first choice for lowering cholesterol.
Ezetimibe is currently only recommended by the regulatory body NICE for people who cannot take a statin.
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Igh LDL cholesterol in the blood is only one of a complex set of factors in the development of heart disease. Lowering it with a drug without addressing lifestyle choices is not good medicine.and one or more other risk factors e. smoking, hypertension, retinopathy, microalbuminuria, macroalbuminuria therapy with atorvastatin 10 mg daily for a median of 3.
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