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157. Grant JE, Odlaug BL, Chamberlain SR, Keuthen NJ, Lochner C, Stein DJ. Skin picking disorder.There is no evidence that memantine prevents or slows neurodegeneration in patients with Alzheimer s disease.
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In memantine hcl 5 mg tablets in which memantine. 8, or 15 mg/kg/day was orally administered on PNDs 7-70, adverse neurobehavioral effects increased locomotor motor activity, increased auditory startle response and decreased habituation, and deficit in learning and memory were observed at all but the lowest dose tested.Although one of the 11 studies was an open-label study ie, not placebo-controlled study 22 the other 10 studies were double-blinded, randomized, placebo-controlled trials.
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