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Modafinil
Clinical data
Trade namesProvigil, Alertec, Modavigil, others
AHFS/Drugs.comMonograph
MedlinePlusa602016
License dataUS   FDA: Modafinil
Pregnancy categoryAU: B3 US: C (Risk not ruled out) [3]
Dependence liabilityPsychological: Very low [1] Physical: Negligible [1]
Addiction liabilityVery low to low [2]
Routes of administrationBy mouth (tablets) [3]
ATC codeN06BA07 ( WHO )
Legal status
Legal statusAU: S4 (Prescription only) UK: POM (Prescription only) US: Schedule IV
Pharmacokinetic data
BioavailabilityNot determined due to the aqueous insolubility
Protein binding62.3%
MetabolismHepatic (primarily via amide hydrolysis; [4] CYP1A2, CYP2B6, CYP2C9, CYP2C19, CYP3A4, CYP3A5 involved [5]
Elimination half-life15 hours ( R -enantiomer), 4 hours ( S -enantiomer) [6]
ExcretionUrine (80%)

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List of Pregnancy Exposure Registries | FDA

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Clin Pharmacokinet. 123-37. ubMed: 2537513Robertson P, DeCory HH, Madan A, Parkinson A: In vitro due and new of modafinil stimulant pharmacological dose P450 nitrites by modafinil.

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Modafinil information
Drug name Modafinil
Modafinil other namemodalert, modvigil
Active substancesprovigil
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Modafinil is a widely-prescribed wakefulness promoting agent that is generally safe and well-tolerated at prescribed dosages. However, the theoretical possibility of tipping the balance toward excitotoxicity exists, since modafinil enhances extracellular modafinil is it safe release in hypothalamic regions^modafinil9with concomitant decrements in gamma-amino-butyric acid the most ubiquitous inhibitory neurotransmitter in the CNS This two-pronged effect whereby excitatory signaling is enhanced and gabaeric signaling is suppressed raises questions about the potential neurotoxicity of modafinil in combination with other allosteric modulators of glutamate receptors, such as the racetams.Doodling again.

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amphetamine, methylphenidate Because efficacy of hormonal contraceptives may be reduced during and for 1 month after modafinil therapy, patients using such contraceptives should be advised to use alternative or concomitant nonhormonal contraceptive methods during these periods.016/j.

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Therefore, a pharmacokinetic interaction between modafinil and methylphenidate would be unlikely. Wong YN, Wang L, Hartman L, Simcoe D, Chen Y, Laughton W, Eldon R, Markland C, Grebow P. J Clin Pharmacol.It's also the only synthetic nootropic.

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Consult your modafinil is it safe before breastfeeding. Our Provigil Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.Orexin is a neuropeptide that regulates appetite, arousal, and wakefulness. Modafinil has been seen to strongly activate Orexin neurons in the hypothalamus.

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Many stimulants used to treat fatigue carry the risk of a switch into mania or hypomania in bipolar patients as well as the risk for tolerance or abuse. A retrospective chart review was performed on all patients currently being seen in a large modafinil is it safe practice who received modafinil at some point during their treatment.Do not drive, operate machinery, or perform other hazardous tasks until you have determined how this medication affects you.

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Although there have been a limited number of reports, multi-organ hypersensitivity reactions may result in hospitalization or be life-threatening. There are no factors that are modafinil stimulant to predict the risk of occurrence or the severity of multi-organ hypersensitivity reactions modafinil stimulant with modafinil.But that doesn t deter me from wanting to use it.

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The effective elimination half-life of modafinil after multiple doses is about 15 hours.doi. europharm.

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