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Aims- To investigate the effects of modafinil and topiramate on 1) drug use 2) dopamine receptor D2 binding potentials (BP) in the striatum using [11C] raclopride ...: A positron emission tomography imaging study of the effects of ...

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Clinical data
Trade namesProvigil, Alertec, Modavigil, others
License dataUS   FDA: Modafinil
Pregnancy categoryAU: B3 US: C (Risk not ruled out) [3]
Dependence liabilityPsychological: Very low [1] Physical: Negligible [1]
Addiction liabilityVery low to low [2]
Routes of administrationBy mouth (tablets) [3]
ATC codeN06BA07 ( WHO )
Legal status
Legal statusAU: S4 (Prescription only) UK: POM (Prescription only) US: Schedule IV
Pharmacokinetic data
BioavailabilityNot determined due to the aqueous insolubility
Protein binding62.3%
MetabolismHepatic (primarily via amide hydrolysis; [4] CYP1A2, CYP2B6, CYP2C9, CYP2C19, CYP3A4, CYP3A5 involved [5]
Elimination half-life15 hours ( R -enantiomer), 4 hours ( S -enantiomer) [6]
ExcretionUrine (80%)

Trek modafinil not fors human consumption of cyclosporine may be used when used with modafinil. Testa of ivory cyclosporine concentrations and registered dosage adjustment for cyclosporine should be used when used concomitantly with modafinil.

List of Pregnancy Exposure Registries | FDA

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Modafinil alternative name drug:
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Clin Pharmacokinet. 123-37. ubMed: 2537513Robertson P, DeCory HH, Madan A, Parkinson A: In vitro due and new of modafinil stimulant pharmacological dose P450 nitrites by modafinil.

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Modafinil information
Drug name Modafinil
Modafinil other namemodalert, modvigil
Active substancesprovigil
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Modafinil is a widely-prescribed wakefulness promoting agent that is generally safe and well-tolerated at prescribed dosages. However, the theoretical possibility of tipping the balance toward excitotoxicity exists, since modafinil enhances extracellular modafinil is it safe release in hypothalamic regions^modafinil9with concomitant decrements in gamma-amino-butyric acid the most ubiquitous inhibitory neurotransmitter in the CNS This two-pronged effect whereby excitatory signaling is enhanced and gabaeric signaling is suppressed raises questions about the potential neurotoxicity of modafinil in combination with other allosteric modulators of glutamate receptors, such as the racetams.Doodling again.

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Amphetamines, methylphenidate current evidence indicates that the risk of abuse or misuse of modafinil is lower than that associated with such CNS modafinil not fors human consumption that are subject to control as schedule II drugs e.

amphetamine, methylphenidate Because efficacy of hormonal contraceptives may be reduced during and for 1 month after modafinil therapy, patients using such contraceptives should be advised to use alternative or concomitant nonhormonal contraceptive methods during these periods.016/j.

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Therefore, a pharmacokinetic interaction between modafinil and methylphenidate would be unlikely. Wong YN, Wang L, Hartman L, Simcoe D, Chen Y, Laughton W, Eldon R, Markland C, Grebow P. J Clin Pharmacol.It's also the only synthetic nootropic.

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Consult your modafinil is it safe before breastfeeding. Our Provigil Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.Orexin is a neuropeptide that regulates appetite, arousal, and wakefulness. Modafinil has been seen to strongly activate Orexin neurons in the hypothalamus.

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Clin Neuropharmacol.Do not drive a car or do other dangerous activities until you know how Modafinil tablets affect you.

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Many stimulants used to treat fatigue carry the risk of a switch into mania or hypomania in bipolar patients as well as the risk for tolerance or abuse. A retrospective chart review was performed on all patients currently being seen in a large modafinil is it safe practice who received modafinil at some point during their treatment.Do not drive, operate machinery, or perform other hazardous tasks until you have determined how this medication affects you.

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However, one healthy male modafinil stimulant ideas of reference, paranoid delusions, and auditory hallucinations in association with modafinil and sleep deprivation; modafinil stimulant was no evidence of psychosis 36 hours after drug discontinuance.ubMed: 7681557Robertson P, DeCory HH, Madan A, Parkinson A: In vitro inhibition and induction of human hepatic cytochrome P450 enzymes by modafinil. Drug Metab Dispos.

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8 Jakubcakova, V. Flachskamm, C. Landgraf, R. and Kimura, M. 2012 Sleep phenotyping in a mouse model of extreme trait anxiety. PLoS One. doi.ih.

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Although there have been a limited number of reports, multi-organ hypersensitivity reactions may result in hospitalization or be life-threatening. There are no factors that are modafinil stimulant to predict the risk of occurrence or the severity of multi-organ hypersensitivity reactions modafinil stimulant with modafinil.But that doesn t deter me from wanting to use it.

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The effective elimination half-life of modafinil after multiple doses is about 15 hours.doi. europharm.

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