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Duloxetine
Clinical data
Trade namesCymbalta, others [1]
AHFS/Drugs.comMonograph
MedlinePlusa604030
License dataEU  EMA:  by INN, US   FDA: duloxetine
Pregnancy categoryAU: B3 US: C (Risk not ruled out)
Routes of administrationBy mouth
Drug classSerotonin–norepinephrine reuptake inhibitor
ATC codeN06AX21 ( WHO )
Legal status
Legal statusAU: S4 (Prescription only) CA : ℞-only UK: POM (Prescription only) US: ℞-only
Pharmacokinetic data
Bioavailability~ 50% (32% to 80%)
Protein binding~ 95%
MetabolismLiver, two P450 isozymes, CYP2D6 and CYP1A2
Elimination half-life12 hours
Excretion70% in urine, 20% in feces

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I would prescribe it to take right before going to bed as it helps you go to sleep which is a common problem for the conditions it is used to treat.14. Major Depressive DisorderThe efficacy of Cymbalta as a treatment for depression was studies in adult outpatients 18 to 83 years meeting DSM-IV criteria for major depression.

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I feel it beating in my chest, jittery, feet and hands feel tingly.The fluid is sent to a laboratory for analysis, which may reveal: Cartilage cells in the fluid are signs of osteoarthritis.

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