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The use of buspirone, tramadol, clomipramine, or amitriptyline with fluoxetine can also increase the risk of serotonin syndrome. Fluoxetine 1 mg, an appetite stimulant, may decrease or even reverse the effect of fluoxetine.ov/medwatch Pimozide: Fluoxetine is contraindicated for use with pimozide due to risk of drug interaction or QTc prolongation. Thioridazine: Fluoxetine is contraindicated for use with thioridazine due to QTc interval prolongation or potential for elevated thioridazine plasma levels.

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