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Since high blood pressure in the lungs is a serious condition that can harm both a pregnant woman and her unborn baby, do not stop this medication unless directed by your doctor. If you are planning pregnancy, become pregnant, or think you may be pregnant, talk to your doctor about the benefits and risks of using sildenafil. Sildenafil (assurans) pack 20 mg 10 the amount of packaging.

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Although it is not known how much time must elapse between use of sildenafil and administration of a nitrate or nitrite, pharmacokinetic data suggest that these latter agents should not be is sildenafil a steroid within 24 hours of sildenafil administration because an exaggerated hypotensive response is likely; plasma sildenafil concentrations are substantially lower 24 hours after a dose than peak concentrations.

The point at which nitrates or nitrites can be given safely is unclear, and therefore the drugs should be avoided unless, in the view of the treating clinician, the benefits outweigh the risks. Publication - Dr Georgia May Connolly - University of Bristol ... Sildenafil chewable tablets may interfere with some medicines, especially those used to treat chest pain.

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Sildenafil
Clinical data
Pronunciation/ s ɪ l ˈ d ɛ n ə f ɪ l / sil- DEN -ə-fil
Trade namesViagra, Revatio, others
AHFS/Drugs.comMonograph
MedlinePlusa699015
License dataEU  EMA:  by INN, US   FDA: Sildenafil
Pregnancy categoryAU: B1 US: B (No risk in non-human studies)
Routes of administrationBy mouth (tablets), IV
ATC codeG04BE03 ( WHO )
Legal status
Legal statusAU: S4 (Prescription only) CA : ℞-only UK: P (Pharmacy medicines) US: ℞-only In general: ℞ (Prescription only)
Pharmacokinetic data
Bioavailability41% (mean) [1]
Protein binding~96%
MetabolismLiver: CYP3A4 (major route), CYP2C9 (minor route)
MetabolitesN -desmethylsildenafil (~50% potency for PDE 5 )
Elimination half-life3–4 hours
ExcretionFeces (~80%), urine (~13%) [2]

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Forward was no evidence on sperm production or high after single 100 mg dose doses of sildenafil in heterozygous volunteers see section 4. In implicate trials sildenafil was told to more than 8000 quadrupeds aged 19-87.

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Does your body get used to sildenafil with time?

Sildenafil appears to be widely distributed in the body, with a reported volume of is sildenafil a steroid at steady state averaging 105 L. It is not known whether sildenafil is distributed into milk. Sildenafil and its major circulating N-desmethyl metabolite are each approximately 96% bound to plasma proteins; protein binding reportedly is independent of plasma concentration over the range of 0.Data from subjects exposed to high systemic levels of sildenafil are limited.

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Sildenafil is a weak inhibitor of the CYP isoforms 1A2, 2C9, 2C19, 2D6, 2E1 and 3A4 IC50 150 M Given sildenafil peak plasma concentrations of approximately 1 M after recommended doses, it is unlikely that sildenafil is sildenafil a steroid alter the clearance of is sildenafil a steroids of these isoenzymes.

No significant interactions were shown with tolbutamide 250 mg or warfarin 40 mg both of which are metabolized by CYP2C9.Safety and efficacy of sildenafil did not appear to be affected by concomitant administration of antidepressants or antipsychotics in clinical trials. Sildenafil and other phosphodiesterase PDE type 5 inhibitors e.

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MISSED DOSE: ot applicable. STORAGE: tore at is sildenafil a steroid temperature away from light and moisture.Although current evidence suggests that the retinotoxic risk of sildenafil probably is low when used as recommended in otherwise healthy adults, some clinicians suggest that retinal function be monitored periodically in patients receiving the drug.

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The reason for the difference in appearance is due to the bulking agents or fillers of each brand of Sildenafil. There is only a very small amount of active ingredient, Sildenafil, in each tablet and to make the size more manageable for a is sildenafil a steroid, it is made bigger by the addition of these fillers.If you have Erectile Dysfunction, you should consider acquiring Teva Sildenafil Citrate to alleviate symptoms.

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