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Along with its needed effects, a medicine may cause some unwanted effects.Curr Neurol Neurosci Rep. 2011 Aug. -70. Medline.

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Likelihood score: E unlikely cause of clinically apparent liver injury The metabolism of levodopa and carbodopa is largely through peripheral or intracellular amino acid decarboxylases, and by catechol-O-methyltransferase and monoamine oxidase in the brain.

They have minimal hepatic metabolism.It is not intended as a substitute for the expertise and judgement of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that the use of any medication in any country is safe, appropriate or effective for you.

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Marketing CategoryApplication Number or Monograph CitationMarketing Start DateMarketing End Date 1NDC: 006-3916-68100in 1 BOTTLE; Type 0: Not a Combination Product.Selected from carbidopa and levodopa sustained releases tablets included with permission and copyrighted by First Databank, Inc.

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Medline. Marks WJ Jr, Bartus RT, Siffert J, et al.Medline. Hauser RA. Future treatments for Parkinson's disease: surfing the PD pipeline.

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Advocates of a neuroprotective effect have suggested that MAO-B inhibitors reduce the formation of neurotoxins through their ability to inhibit dopamine levodopa carbidopa interaction. This potential benefit was first reported in 1989 in the DATATOP Deprenyl and Tocopherol Antioxidative Therapy of Parkinsonism trial of selegiline.This medicine is known as a levodopa therapy.

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Keep a list of all the products you use including prescription/nonprescription drugs and herbal products and share it with your doctor and pharmacist.For the reasons stated above, patients and providers are advised to monitor for melanomas frequently and on a regular basis when using SINEMET for any indication.

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