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Sertraline
Clinical data
Pronunciation/ ˈ s ə r t r ə ˌ l iː n /
Trade namesZoloft and others [1]
AHFS/Drugs.comMonograph
MedlinePlusa697048
Pregnancy categoryAU: C US: C (Risk not ruled out)
Routes of administrationBy mouth (tablets and solution)
Drug classSelective serotonin reuptake inhibitor
ATC codeN06AB06 ( WHO )
Legal status
Legal statusAU: S4 (Prescription only) UK: POM (Prescription only) US: ℞-only In general: ℞ (Prescription only)
Pharmacokinetic data
Bioavailability44%
Protein binding98.5%
MetabolismHepatic ( N -demethylation mainly by CYP2B6) [2]
Metabolitesnorsertraline
Elimination half-life~23–26 h (66 h [less-active [3] metabolite, norsertraline]) [4] [5] [6] [7]
ExcretionRenal

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Each site obtained study approval from its institutional review board and written informed consent from all patients. Patients were randomly assigned by computer-generated numbers to 10 weeks of double-blind treatment with either sertraline or zoloft and bipolar ii effectiveness of ZOLOFT for PMDD for more than 3 menstrual cycles has not been systematically evaluated in controlled trials.

Luteal Phase Dysphoric Disorder LLPDD the clinical entity referred to as PMDD in DSM-IV.

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